Dendrodendritic Inhibition and Simulated Odor Responses in a Detailed Olfactory Bulb Network Model
This is a model of the mammalian olfactory bulb for the
NEURON simulator. The model contains only mitral and
granule cells.
It is intended that the properties of the network can be
explored by changing the files parameters_<xxx>.hoc and
experiment_<xxx>.hoc. It should not be necessary to change
the other files.
After compiling the mod files, start the simulation by
running init.hoc Type show_results() if after running the
odour stimulus simulation the mitral cell spike time
histogram graph is empty.
Abstract
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In the olfactory bulb, both the spatial distribution and the temporal structure of neuronal activity appear to be important for processing odor information, but it is currently impossible to measure both of these simultaneously with high resolution and in all layers of the bulb. We have developed a biologically realistic model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them, which allows us to observe the network behavior in detail. The cell models were based on previously published work. The attributes of the synapses were obtained from the literature. The pattern of synaptic connections was based on the limited experimental data in the literature on the statistics of connections between neurons in the bulb. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. This gives confidence that the model is capturing features of network interactions in the real olfactory bulb. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. Preliminary experiments suggest that slow temporal changes in the degree of synchronization are more useful in distinguishing between very similar odorants than is the spatial distribution of mean firing rate.
Davison,
A.,
J.
Feng,
and
D.
Brown,
"Dendrodendritic Inhibition and Simulated Odor Responses in a Detailed Olfactory Bulb Network Model",
Journal of Neurophysiology
, 90, 1921-1935.
Coder:


-
Andrew Davison
UNIC, CNRS UPR 3293
France
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Bartlett's Formula for a General Class of Non Linear Processes
Abstract
Close
A Bartlett-type formula is proposed for the asymptotic distribution of the sample autocorrelations of nonlinear processes. The asymptotic covariances between sample autocorrelations are expressed as the sum of two terms. The first term corresponds to the standard Bartlett's formula for linear processes, involving only the autocorrelation function of the observed process. The second term, which is specific to nonlinear processes, involves the autocorrelation function of the observed process, the kurtosis of the linear innovation process and the autocorrelation function of its square. This formula is obtained under a symmetry assumption on the linear innovation process. It is illustrated on ARMA–GARCH models and compared to the standard formula. An empirical application on financial time series is proposed.
Francq,
C.,
and
J.
Zakoian,
"Bartlett's Formula for a General Class of Non Linear Processes",
Journal of Time Series Analysis, 30, 449-465.
|
Francq Zakoian |
Francq Zakoian |
07/23/2012 | 8 | 522 | 111 |
|
Kinematics of the ribbon fin in hovering and swimming of the electric ghost knifefish
Abstract
Close
Weakly electric knifefish are exceptionally maneuverable swimmers. In prior work, we have shown that they are able to move their entire body omnidirectionally so that they can rapidly reach prey up to several centimeters away. Consequently, in addition to being a focus of efforts to understand the neural basis of sensory signal processing in vertebrates, knifefish are increasingly the subject of biomechanical analysis to understand the coupling of signal acquisition and biomechanics. Here, we focus on a key subset of the knifefish's omnidirectional mechanical abilities: hovering in place, and swimming forward at variable speed. Using high-speed video and a markerless motion capture system to capture fin position, we show that hovering is achieved by generating two traveling waves, one from the caudal edge of the fin and one from the rostral edge, moving toward each other. These two traveling waves overlap at a nodal point near the center of the fin, cancelling fore-aft propulsion. During forward swimming at low velocities, the caudal region of the fin continues to have counter-propagating waves, directly retarding forward movement. The gait transition from hovering to forward swimming is accompanied by a shift in the nodal point toward the caudal end of the fin. While frequency varies significantly to increase speed at low velocities, beyond approximately one body length per second, the frequency stays near 10 Hz, and amplitude modulation becomes more prominent. A coupled central pattern generator model is able to reproduce qualitative features of fin motion and suggest hypotheses regarding the fin's neural control.
Ruiz-Torres,
R.,
M.
A.
MacIver,
"Kinematics of the ribbon fin in hovering and swimming of the electric ghost knifefish",
Journal of Experimental Biology, 1.
|
Ruiz-Torres Curet Lauder MacIver |
Ruiz-Torres MacIver |
02/19/2013 | 9999 | 17 | N.A. |
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